{"id":1550,"date":"2023-12-15T09:50:14","date_gmt":"2023-12-15T09:50:14","guid":{"rendered":"https:\/\/diarisanitat.cat\/recerca-en-salut\/?p=1550"},"modified":"2024-07-08T15:15:11","modified_gmt":"2024-07-08T15:15:11","slug":"mes-esperanca-de-vida-per-a-pacients-amb-cancer-de-coll-duter-metastasic","status":"publish","type":"post","link":"https:\/\/diarisanitat.cat\/recerca-en-salut\/blog\/2023\/12\/15\/mes-esperanca-de-vida-per-a-pacients-amb-cancer-de-coll-duter-metastasic\/","title":{"rendered":"M\u00e9s esperan\u00e7a de vida per a pacients amb c\u00e0ncer de coll d\u2019\u00fater metast\u00e0sic"},"content":{"rendered":"

Un assaig cl\u00ednic internacional liderat des de Barcelona mostra que afegir immunoter\u00e0pia al tractament est\u00e0ndard del c\u00e0ncer de c\u00e8rvix millora significativament la superviv\u00e8ncia de les pacients, disminuint el 32% el risc de morir per la malaltia.<\/p>\n

En el c\u00e0ncer, les c\u00e8l\u00b7lules tumorals, no nom\u00e9s destrueixen altres c\u00e8l\u00b7lules en la lluita que desencadena la malaltia, sin\u00f3 que en molts casos amaguen la seva mal\u00edcia, enganyant aix\u00ed el sistema immunitari, on hi ha la defensa del nostre organisme per a combatre-les com a agents estranys. Una prote\u00efna, de nom PDL1, en c\u00e8l\u00b7lules canceroses, pot evitar la destrucci\u00f3 d\u2019aquestes c\u00e8l\u00b7lules dolentes amb aquest camuflatge que enganya. I, com que evitar la destrucci\u00f3 i, per tant, la proliferaci\u00f3 de les c\u00e8l\u00b7lules tumorals \u00e9s part del tractament m\u00e8dic i un dels fronts oberts de la comunitat cient\u00edfica que investiga en oncologia l\u2019origen, causes i maneres del desenvolupament tumoral, trobar mecanismes per evitar l\u2019engany del sistema immunitari \u00e9s una de les dianes d\u2019estudi.<\/p>\n

Recentment, i tal com s\u2019ha fet ress\u00f2 a la revista cient\u00edfica The Lancet<\/a><\/em>, un assaig cl\u00ednic internacional liderat des de Barcelona ha mostrat un augment de la superviv\u00e8ncia de pacients amb c\u00e0ncer de coll d\u2019\u00fater metast\u00e0sic al tractament est\u00e0ndard de les quals s\u2019ha afegit un inhibidor del punt de control de PDL1, perqu\u00e8 no puguin ser passades per alt les c\u00e8l\u00b7lules canceroses.<\/p>\n

\u201cHa estat un estudi aleatoritzat que va incloure 410 pacients d\u2019Europa, Estats Units i Jap\u00f3, totes amb c\u00e0ncer de c\u00e8rvix metast\u00e0sic recurrent, no candidates a cap tractament local, ni radioter\u00e0pia ni cirurgia, i es dividien a l\u2019atzar en dos grups. Se\u2019ls va fer un seguiment de trenta-cinc mesos. Unes seguien el tractament est\u00e0ndard i les altres, l\u2019experimental, mantenint els mateixos f\u00e0rmacs de l\u2019est\u00e0ndard, per\u00f2 afegint-hi un agent d\u2019immunoter\u00e0pia, l\u2019inhibidor del punt de control de PDL1\u201d, explica la doctora Ana Oaknin, investigadora principal i primera autora d’aquest estudi.<\/p>\n

\"\"<\/a>
Ana Oakin<\/figcaption><\/figure>\n

Els resultats mostren una mitjana de superviv\u00e8ncia general de 32,1 mesos en pacients que van rebre l\u2019inhibidor del punt de control de PDL1 (atezolizumab) m\u00e9s bevacizumab i quimioter\u00e0pia, enfront dels 22,8 mesos en pacients que van rebre l’opci\u00f3 est\u00e0ndard de tractament, bevacizumab m\u00e9s quimioter\u00e0pia. \u201cS\u00f3n resultats molt satisfactoris, per la superviv\u00e8ncia lliure de progressi\u00f3, aconseguida, \u00e9s a dir, el temps que triga la pacient a que la malaltia pugui tornar a cr\u00e9ixer. I tamb\u00e9 creix la superviv\u00e8ncia global. Hem vist com l\u2019\u00fas de la immunoter\u00e0pia perllonga de forma significativa la superviv\u00e8ncia global. Al cap de dos anys, amb el tractament convencional, nom\u00e9s el 49% de les pacients eren vives, mentre que afegint la immunoter\u00e0pia, als dos anys eren el 61% de les pacients les que sobrevivien. D\u2019aquesta manera, disminueix un 32% el risc que la pacient pugui morir per la malaltia.<\/p>\n

Ara, el seg\u00fcent pas -explica la Dra. Oaknin- \u201c\u00e9s aconseguir que aquest tractament el puguin rebre totes les pacients\u201d. Per aix\u00f2, ha de ser aprovat per les ag\u00e8ncies reguladores, tant l\u2019europea com la nord-americana, i en aix\u00f2 treballen, segons diu la investigadora principal de l\u2019assaig. \u201cTant de bo l\u2019any 2024 puguem comptar amb aquest tractament per a totes les pacients que siguin candidates a ell\u201d.<\/p>\n

Les pacients amb c\u00e0ncer de coll uter\u00ed metast\u00e0tic, recurrent o persistent no susceptible de ser tractades amb cirurgia o radioter\u00e0pia, tenen un pron\u00f2stic molt pobre.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un assaig cl\u00ednic internacional liderat des de Barcelona mostra que afegir immunoter\u00e0pia al tractament est\u00e0ndard del c\u00e0ncer de c\u00e8rvix millora significativament la superviv\u00e8ncia de les pacients, disminuint el 32% el risc de morir per la malaltia. En el c\u00e0ncer, les c\u00e8l\u00b7lules tumorals, no nom\u00e9s destrueixen altres c\u00e8l\u00b7lules en la lluita que desencadena la malaltia, sin\u00f3<\/p>\n","protected":false},"author":16,"featured_media":1551,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1385,126],"tags":[],"tipo":[],"class_list":{"0":"post-1550","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-esperanca-de-vida","8":"category-recerca"},"acf":[],"yoast_head":"\nM\u00e9s esperan\u00e7a de vida per a pacients amb c\u00e0ncer de coll d\u2019\u00fater metast\u00e0sic - Recerca en salut<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/diarisanitat.cat\/recerca-en-salut\/blog\/2023\/12\/15\/mes-esperanca-de-vida-per-a-pacients-amb-cancer-de-coll-duter-metastasic\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00e9s esperan\u00e7a de vida per a pacients amb c\u00e0ncer de coll d\u2019\u00fater metast\u00e0sic - Recerca en salut\" \/>\n<meta property=\"og:description\" content=\"Un assaig cl\u00ednic internacional liderat des de Barcelona mostra que afegir immunoter\u00e0pia al tractament est\u00e0ndard del c\u00e0ncer de c\u00e8rvix millora significativament la superviv\u00e8ncia de les pacients, disminuint el 32% el risc de morir per la malaltia. 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