{"id":445,"date":"2022-12-05T13:40:13","date_gmt":"2022-12-05T13:40:13","guid":{"rendered":"https:\/\/diarisanitat.cat\/recerca-en-salut\/?p=445"},"modified":"2024-07-08T15:14:42","modified_gmt":"2024-07-08T15:14:42","slug":"estudiar-el-microbioma-per-predir-el-transcurs-de-la-infeccio-pel-sars-cov-2-i-el-vih","status":"publish","type":"post","link":"https:\/\/diarisanitat.cat\/recerca-en-salut\/blog\/2022\/12\/05\/estudiar-el-microbioma-per-predir-el-transcurs-de-la-infeccio-pel-sars-cov-2-i-el-vih\/","title":{"rendered":"Estudiar el microbioma per predir el transcurs de la infecci\u00f3 pel SARS-CoV-2 i el VIH"},"content":{"rendered":"

Con\u00e8ixer si una infecci\u00f3 pot evolucionar cap a una malaltia amb simptomatologia greu ha sigut sempre un objectiu important per la comunitat m\u00e8dica, ja que predir aquest risc milloraria l\u2019atenci\u00f3 sanit\u00e0ria de les persones afectades. En el context de la pand\u00e8mia de la Covid-19, aquest objectiu ha passat a ser prioritari. En aquest sentit, s\u00f3n diversos els estudis que recolzen la utilitat de la composici\u00f3 del microbioma com a potencial eina de pron\u00f2stic d\u2019evoluci\u00f3 de malalties infeccioses, tals com la Covid-19 i el VIH\/sida.<\/p>\n

Aquest, entre d\u2019altres, ser\u00e0 un dels temes que es tractaran al\u00a0The Barcelona Debates on the Human Microbiome 202<\/em><\/a>2, que tindr\u00e0 lloc el 30 de juny i l\u20191 de juliol al CosmoCaixa. El debat est\u00e0 organitzat per l\u2019Institut de Recerca de la Sida IrsiCaixa<\/a>\u00a0\u2013centre impulsat conjuntament per la Fundaci\u00f3 \u201cla Caixa\u201d i el Departament de Salut de la Generalitat de Catalunya\u2013 i compta amb la Fundaci\u00f3 \u201cla Caixa\u201d com a patrocinadora principal, aix\u00ed com amb el suport log\u00edstic de FLS Science.<\/p>\n

El congr\u00e9s, que enguany celebra la seva vuitena edici\u00f3, est\u00e0 coordinat pel director d\u2019IrsiCaixa Bonaventura Clotet, el metge em\u00e8rit de la Unitat d\u2019Investigaci\u00f3 del Sistema Digestiu de l\u2019Institut de Recerca de l\u2019Hospital Vall d\u2019Hebron Francisco Guarner i l\u2019investigador principal a IrsiCaixa i cap del Servei de Malalties Infeccioses de l\u2019Hospital Germans Trias i Pujol Roger Paredes. \u201cPoder reunir en un mateix espai experts i expertes de tot el m\u00f3n en el camp del microbioma \u00e9s una excel\u00b7lent oportunitat per compartir el coneixement m\u00e9s actual en aquesta \u00e0rea\u201d, celebra Guarner.<\/p>\n

\u201cPortem anys estudiant el microbioma i com la seva composici\u00f3 influeix en la salut humana. Existeixen patrons infinits en quant al tipus de microbis que conformen el nostre microbioma, i cadascun d\u2019aquests patrons influeix d\u2019una manera determinada a com responen les nostres defenses davant un agent infecci\u00f3s, com pot ser el VIH o el SARS-CoV-2\u201d, explica Paredes.<\/p>\n

Un dels temes que es tractaran al congr\u00e9s \u00e9s com el microbioma, en aquest cas pulmonar, pot arribar a influir en el transcurs de la Covid-19. \u201cA partir d\u2019un estudi en el que han participat gaireb\u00e9 100 persones hospitalitzades per aquesta i altres malalties greus, hem pogut demostrar que existeix una difer\u00e8ncia real entre el microbioma pulmonar de les persones ingressades per Covid-19 i les ingressades per altres dol\u00e8ncies\u201d, explica Frederic Bushman, ponent a l\u2019esdeveniment i catedr\u00e0tic de Microbiologia de la Universitat de Pennsilv\u00e0nia.<\/p>\n

\u201cHem observat que, en el cas de les persones amb Covid-19 greu, el seu microbioma pulmonar, concretament a la part superior de la faringe situada rere la boca i anomenada orofaringe, presenta un major desequilibri que s\u2019associa a un estat d\u2019inflamaci\u00f3 sist\u00e8mica. De fet, podria ser una mol\u00e8cula caracter\u00edstica d\u2019aquesta inflamaci\u00f3 la que potenci\u00e9s la funci\u00f3 del receptor que permet l\u2019entrada del SARS-CoV- 2 a les c\u00e8l\u00b7lules, facilitant l\u2019expansi\u00f3 del virus pel cos\u201d, afegeix.<\/p>\n

A m\u00e9s a m\u00e9s, mitjan\u00e7ant l\u2019\u00fas de t\u00e8cniques d\u2019Intel\u00b7lig\u00e8ncia Artificial, l\u2019estudi de Bushman demostra que les mostres de microbioma obtingudes de l\u2019orofaringe als estadis m\u00e9s inicials de la infecci\u00f3 pel SARS-CoV-2 tenen un gran potencial a l\u2019hora de predir la gravetat de la Covid- 19.<\/p>\n

\u201cLes fites assolides fins ara en el camp del microbioma ens confirmen un cop m\u00e9s la import\u00e0ncia de potenciar la recerca en aquesta \u00e0rea. Disposar d\u2019una eina que ens permeti con\u00e8ixer des d\u2019un inici com ser\u00e0 l\u2019evoluci\u00f3 d\u2019una infecci\u00f3 ens permetr\u00e0 realitzar diagn\u00f2stics m\u00e9s acurats i millorar l\u2019atenci\u00f3 m\u00e8dica dels i les pacients\u201d, conclou Clotet.<\/p>\n","protected":false},"excerpt":{"rendered":"

Del 30 de juny a l\u20191 de juliol tindr\u00e0 lloc el The Barcelona Debates on the Human Microbiome el congr\u00e9s m\u00e9s important en el camp del microbioma a nivell nacional<\/p>\n","protected":false},"author":725,"featured_media":446,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1352,126],"tags":[],"tipo":[],"class_list":{"0":"post-445","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-irsi-caixa-institut-de-recerca-de-la-sida-c","8":"category-recerca"},"acf":[],"yoast_head":"\nEstudiar el microbioma per predir el transcurs de la infecci\u00f3 pel SARS-CoV-2 i el VIH - Recerca en salut<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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